d - Two evening exams on February 1st and February 22nd - both 1900-2050.
f - Pending approval will be offered as BI 281H Honors Biology I: Genetics and Molecular Biology
Course Data
BI 252 Found II: Genet/Molec >3
5.00 cr.
How living organisms store, replicate, and transmit their genetic information, and how this information directs the activities of the cell and organism. Lectures, laboratories.
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Expanded Course Description
In this course we will examine the genetic and molecular mechanisms responsible for the inheritance of physical characteristics, cell division, the regulation of genes, and the development of different cell types from a common cell. We will begin with the key roles of DNA and RNA as informational molecules: what structures they take, how they are synthesized, and how cells pass this information to subsequent generations. We will then examine the ultimate expression of information in the synthesis of proteins from the code carried in DNA and RNA. We will then go from the level of the molecules of heredity to the level of the physical manifestation of them by examining some inherited metabolic diseases, and the early genetic principles learned from study of those diseases. We will study inheritance by first analyzing the experiments that demonstrated genes are carried by chromosomes. Several modes of inheritance will be examined, and this will lead us to the phenomenon of genetic linkage, and how it applies to the determination of the order of and distances between genes on a chromosome. We will discuss proteins that regulate specific cellular characteristics, and how cells respond to changing conditions by altering their pattern of protein production. This will allow us to finish the course with a molecular genetic perspective of development: how a cell that begins its life with several developmental options becomes "committed" to adopting one specific form and function.
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